ea0016p693 | Thyroid | ECE2008
Lucchi Simona
, de Filippis Tiziana
, Calebiro Davide
, Porazzi Patrizia
, Spada Anna
, Persani Luca
Tools that are highly effective in the treatment of differentiated thyroid cancer (DTC) loose their therapeutic potentials in poorly differentiated tumors. The synthetic analog 8-Cl-cAMP has been known to have an antiproliferative effect in a variety of cancer cells and is tested as antineoplastic agent in clinical trials. The signaling mechanisms that govern the 8-Cl-cAMP-induced growth inhibition are still uncertain and data in thyroid neoplasia are lacking. Therefore, we te...